NUTRITION SENSING MECHANISMS
Nutrition-sensing systems regulate the body's response to food intake, impacting longevity. Rodents with lowered calorie and triglyceride-to-HDL ratios exhibit greater life expectancy. Targeting specific foods rather than overall calorie restriction is more effective in extending lifespan. Certain supplements like NMN and Resveratrol may address nutritional deficiencies and support metabolic health.
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PROTEOMICS
Enzyme pathways, intracellular signalling, and cellular homeostasis rely on proteins. That is why high-density proteins are the most crucial component of human cells. Through a mechanism called protein homeostasis, cells ensure that proteins are in an optimal state to function. When our cells practice protein homeostasis, they ensure optimal protein levels. (10) Protein folding, degradation, and synthesis are controlled by different aging biomarkers mechanisms that work together to maintain lipoprotein proteostasis. The proteasome and autophagy, a recycling mechanism, are primarily responsible for the degradation of misfolded and damaged high-density proteins.Proteostasis declines with age, leading to an increase in protein dysfunction and degradation. Aggregates created by misfolded high-density proteins are a hallmark of several age-related neurological disorders, including Parkinson’s, Alzheimer’s, and damaging triglyceride structures. So, for our cells to work properly all the time, it is crucial to keep our protein levels constant. (11) A supplement regimen including NMN, Glycine, and Apigenin may assist with protein homeostasis leading to an increased lifespan.
STEM CELL EXHAUSTION
Keep stem cells in mind. Surprisingly, they have the potential to differentiate into every kind of cell found in the body. Mainly, they help maintain the health of our internal organs and tissues. Their numbers always decrease with age, which may lead to problems, including a compromised immune system and delayed recovery. Our immune systems' ability to generate enough new blood cells and triglyceride structures declines with age, making us more vulnerable to illness. Another concern is that our bodies may not be able to repair themselves, which might result in issues like memory loss and heart disease. (12) Calorie restriction and fast-mimicking diets are two dietary strategies that may increase cell health. Nutritional supplements such NMN, Ca-AKG and resveratrol may assist with stem cell revitalization leading to better health.